Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice
Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
Frontiers Media
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/43930/ |