Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice
We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) with contrasting pathogenicities in mice. We found that four amino acid mutations (P224S in t...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
American Society for Microbiology
2014
|
| Online Access: | https://eprints.nottingham.ac.uk/43920/ |