Reconstruction and simulation of neocortical microcircuitry
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical met...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/42775/ |
| _version_ | 1848796564475084800 |
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| author | Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado Ailamaki, Anastasia Alonso-Nanclares, Lidia Antille, Nicolas Arsever, Selim Kahou, Guy Antoine Atenekeng Berger, Thomas K. Bilgili, Ahmet Buncic, Nenad Chalimourda, Athanassia Chindemi, Giuseppe Courcol, Jean-Denis Delalondre, Fabien Delattre, Vincent Druckmann, Shaul Dumusc, Raphael Dynes, James Eilemann, Stefan Gal, Eyal Gevaert, Michael Emiel Ghobril, Jean-Pierre Gidon, Albert Graham, Joe W. Gupta, Anirudh Haenel, Valentin Hay, Etay Heinis, Thomas Hernando, Juan B. Hines, Michael Kanari, Lida Keller, Daniel Kenyon, John Khazen, Georges Kim, Yihwa King, James G. Kisvarday, Zoltan Kumbhar, Pramod Lasserre, Sébastien Le Bé, Jean-Vincent Magalhães, Bruno R.C. Merchán-Pérez, Angel Meystre, Julie Morrice, Benjamin Roy Muller, Jeffrey Muñoz-Céspedes, Alberto Muralidhar, Shruti Muthurasa, Keerthan Nachbaur, Daniel Newton, Taylor H. Nolte, Max Ovcharenko, Aleksandr Palacios, Juan Pastor, Luis Perin, Rodrigo Ranjan, Rajnish Riachi, Imad Rodríguez, José-Rodrigo Riquelme, Juan Luis Rössert, Christian Sfyrakis, Konstantinos Shi, Ying Shillcock, Julian C. Silberberg, Gilad Silva, Ricardo Tauheed, Farhan Telefont, Martin Toledo-Rodriguez, Maria Tränkler, Thomas Van Geit, Werner Díaz, Jafet Villafranca Walker, Richard Wang, Yun Zaninetta, Stefano M. DeFelipe, Javier Hill, Sean L. Segev, Idan Schürmann, Felix |
| author_facet | Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado Ailamaki, Anastasia Alonso-Nanclares, Lidia Antille, Nicolas Arsever, Selim Kahou, Guy Antoine Atenekeng Berger, Thomas K. Bilgili, Ahmet Buncic, Nenad Chalimourda, Athanassia Chindemi, Giuseppe Courcol, Jean-Denis Delalondre, Fabien Delattre, Vincent Druckmann, Shaul Dumusc, Raphael Dynes, James Eilemann, Stefan Gal, Eyal Gevaert, Michael Emiel Ghobril, Jean-Pierre Gidon, Albert Graham, Joe W. Gupta, Anirudh Haenel, Valentin Hay, Etay Heinis, Thomas Hernando, Juan B. Hines, Michael Kanari, Lida Keller, Daniel Kenyon, John Khazen, Georges Kim, Yihwa King, James G. Kisvarday, Zoltan Kumbhar, Pramod Lasserre, Sébastien Le Bé, Jean-Vincent Magalhães, Bruno R.C. Merchán-Pérez, Angel Meystre, Julie Morrice, Benjamin Roy Muller, Jeffrey Muñoz-Céspedes, Alberto Muralidhar, Shruti Muthurasa, Keerthan Nachbaur, Daniel Newton, Taylor H. Nolte, Max Ovcharenko, Aleksandr Palacios, Juan Pastor, Luis Perin, Rodrigo Ranjan, Rajnish Riachi, Imad Rodríguez, José-Rodrigo Riquelme, Juan Luis Rössert, Christian Sfyrakis, Konstantinos Shi, Ying Shillcock, Julian C. Silberberg, Gilad Silva, Ricardo Tauheed, Farhan Telefont, Martin Toledo-Rodriguez, Maria Tränkler, Thomas Van Geit, Werner Díaz, Jafet Villafranca Walker, Richard Wang, Yun Zaninetta, Stefano M. DeFelipe, Javier Hill, Sean L. Segev, Idan Schürmann, Felix |
| author_sort | Markram, Henry |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. |
| first_indexed | 2025-11-14T19:49:59Z |
| format | Article |
| id | nottingham-42775 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:59Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-427752020-05-04T17:20:02Z https://eprints.nottingham.ac.uk/42775/ Reconstruction and simulation of neocortical microcircuitry Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado Ailamaki, Anastasia Alonso-Nanclares, Lidia Antille, Nicolas Arsever, Selim Kahou, Guy Antoine Atenekeng Berger, Thomas K. Bilgili, Ahmet Buncic, Nenad Chalimourda, Athanassia Chindemi, Giuseppe Courcol, Jean-Denis Delalondre, Fabien Delattre, Vincent Druckmann, Shaul Dumusc, Raphael Dynes, James Eilemann, Stefan Gal, Eyal Gevaert, Michael Emiel Ghobril, Jean-Pierre Gidon, Albert Graham, Joe W. Gupta, Anirudh Haenel, Valentin Hay, Etay Heinis, Thomas Hernando, Juan B. Hines, Michael Kanari, Lida Keller, Daniel Kenyon, John Khazen, Georges Kim, Yihwa King, James G. Kisvarday, Zoltan Kumbhar, Pramod Lasserre, Sébastien Le Bé, Jean-Vincent Magalhães, Bruno R.C. Merchán-Pérez, Angel Meystre, Julie Morrice, Benjamin Roy Muller, Jeffrey Muñoz-Céspedes, Alberto Muralidhar, Shruti Muthurasa, Keerthan Nachbaur, Daniel Newton, Taylor H. Nolte, Max Ovcharenko, Aleksandr Palacios, Juan Pastor, Luis Perin, Rodrigo Ranjan, Rajnish Riachi, Imad Rodríguez, José-Rodrigo Riquelme, Juan Luis Rössert, Christian Sfyrakis, Konstantinos Shi, Ying Shillcock, Julian C. Silberberg, Gilad Silva, Ricardo Tauheed, Farhan Telefont, Martin Toledo-Rodriguez, Maria Tränkler, Thomas Van Geit, Werner Díaz, Jafet Villafranca Walker, Richard Wang, Yun Zaninetta, Stefano M. DeFelipe, Javier Hill, Sean L. Segev, Idan Schürmann, Felix We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. Elsevier 2015-10-08 Article PeerReviewed Markram, Henry, Muller, Eilif, Ramaswamy, Srikanth, Reimann, Michael W., Abdellah, Marwan, Sanchez, Carlos Aguado, Ailamaki, Anastasia, Alonso-Nanclares, Lidia, Antille, Nicolas, Arsever, Selim, Kahou, Guy Antoine Atenekeng, Berger, Thomas K., Bilgili, Ahmet, Buncic, Nenad, Chalimourda, Athanassia, Chindemi, Giuseppe, Courcol, Jean-Denis, Delalondre, Fabien, Delattre, Vincent, Druckmann, Shaul, Dumusc, Raphael, Dynes, James, Eilemann, Stefan, Gal, Eyal, Gevaert, Michael Emiel, Ghobril, Jean-Pierre, Gidon, Albert, Graham, Joe W., Gupta, Anirudh, Haenel, Valentin, Hay, Etay, Heinis, Thomas, Hernando, Juan B., Hines, Michael, Kanari, Lida, Keller, Daniel, Kenyon, John, Khazen, Georges, Kim, Yihwa, King, James G., Kisvarday, Zoltan, Kumbhar, Pramod, Lasserre, Sébastien, Le Bé, Jean-Vincent, Magalhães, Bruno R.C., Merchán-Pérez, Angel, Meystre, Julie, Morrice, Benjamin Roy, Muller, Jeffrey, Muñoz-Céspedes, Alberto, Muralidhar, Shruti, Muthurasa, Keerthan, Nachbaur, Daniel, Newton, Taylor H., Nolte, Max, Ovcharenko, Aleksandr, Palacios, Juan, Pastor, Luis, Perin, Rodrigo, Ranjan, Rajnish, Riachi, Imad, Rodríguez, José-Rodrigo, Riquelme, Juan Luis, Rössert, Christian, Sfyrakis, Konstantinos, Shi, Ying, Shillcock, Julian C., Silberberg, Gilad, Silva, Ricardo, Tauheed, Farhan, Telefont, Martin, Toledo-Rodriguez, Maria, Tränkler, Thomas, Van Geit, Werner, Díaz, Jafet Villafranca, Walker, Richard, Wang, Yun, Zaninetta, Stefano M., DeFelipe, Javier, Hill, Sean L., Segev, Idan and Schürmann, Felix (2015) Reconstruction and simulation of neocortical microcircuitry. Cell, 163 (2). pp. 456-492. ISSN 0092-8674 http://www.sciencedirect.com/science/article/pii/S0092867415011915 doi:10.1016/j.cell.2015.09.029 doi:10.1016/j.cell.2015.09.029 |
| spellingShingle | Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado Ailamaki, Anastasia Alonso-Nanclares, Lidia Antille, Nicolas Arsever, Selim Kahou, Guy Antoine Atenekeng Berger, Thomas K. Bilgili, Ahmet Buncic, Nenad Chalimourda, Athanassia Chindemi, Giuseppe Courcol, Jean-Denis Delalondre, Fabien Delattre, Vincent Druckmann, Shaul Dumusc, Raphael Dynes, James Eilemann, Stefan Gal, Eyal Gevaert, Michael Emiel Ghobril, Jean-Pierre Gidon, Albert Graham, Joe W. Gupta, Anirudh Haenel, Valentin Hay, Etay Heinis, Thomas Hernando, Juan B. Hines, Michael Kanari, Lida Keller, Daniel Kenyon, John Khazen, Georges Kim, Yihwa King, James G. Kisvarday, Zoltan Kumbhar, Pramod Lasserre, Sébastien Le Bé, Jean-Vincent Magalhães, Bruno R.C. Merchán-Pérez, Angel Meystre, Julie Morrice, Benjamin Roy Muller, Jeffrey Muñoz-Céspedes, Alberto Muralidhar, Shruti Muthurasa, Keerthan Nachbaur, Daniel Newton, Taylor H. Nolte, Max Ovcharenko, Aleksandr Palacios, Juan Pastor, Luis Perin, Rodrigo Ranjan, Rajnish Riachi, Imad Rodríguez, José-Rodrigo Riquelme, Juan Luis Rössert, Christian Sfyrakis, Konstantinos Shi, Ying Shillcock, Julian C. Silberberg, Gilad Silva, Ricardo Tauheed, Farhan Telefont, Martin Toledo-Rodriguez, Maria Tränkler, Thomas Van Geit, Werner Díaz, Jafet Villafranca Walker, Richard Wang, Yun Zaninetta, Stefano M. DeFelipe, Javier Hill, Sean L. Segev, Idan Schürmann, Felix Reconstruction and simulation of neocortical microcircuitry |
| title | Reconstruction and simulation of neocortical microcircuitry |
| title_full | Reconstruction and simulation of neocortical microcircuitry |
| title_fullStr | Reconstruction and simulation of neocortical microcircuitry |
| title_full_unstemmed | Reconstruction and simulation of neocortical microcircuitry |
| title_short | Reconstruction and simulation of neocortical microcircuitry |
| title_sort | reconstruction and simulation of neocortical microcircuitry |
| url | https://eprints.nottingham.ac.uk/42775/ https://eprints.nottingham.ac.uk/42775/ https://eprints.nottingham.ac.uk/42775/ |