A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology
This short review considers the range of modern techniques for the hydrodynamic characterisation of macromolecules – particularly large glycosylated systems used in the food, biopharma and healthcare industries. The range or polydispersity of molecular weights and conformations presents special chal...
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| Format: | Article |
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Taylor & Francis
2015
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| Online Access: | https://eprints.nottingham.ac.uk/42765/ |
| _version_ | 1848796562176606208 |
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| author | Gillis, Richard B. Rowe, Arthur J. Adams, Gary G. Harding, Stephen E. |
| author_facet | Gillis, Richard B. Rowe, Arthur J. Adams, Gary G. Harding, Stephen E. |
| author_sort | Gillis, Richard B. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | This short review considers the range of modern techniques for the hydrodynamic characterisation of macromolecules – particularly large glycosylated systems used in the food, biopharma and healthcare industries. The range or polydispersity of molecular weights and conformations presents special challenges compared to proteins. The review is aimed, without going into any great theoretical or methodological depth, to help the Industrial Biotechnologist choose the appropriate methodology or combination of methodologies for providing the detail he/she needs for particular applications. |
| first_indexed | 2025-11-14T19:49:57Z |
| format | Article |
| id | nottingham-42765 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:57Z |
| publishDate | 2015 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-427652020-05-04T17:05:00Z https://eprints.nottingham.ac.uk/42765/ A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology Gillis, Richard B. Rowe, Arthur J. Adams, Gary G. Harding, Stephen E. This short review considers the range of modern techniques for the hydrodynamic characterisation of macromolecules – particularly large glycosylated systems used in the food, biopharma and healthcare industries. The range or polydispersity of molecular weights and conformations presents special challenges compared to proteins. The review is aimed, without going into any great theoretical or methodological depth, to help the Industrial Biotechnologist choose the appropriate methodology or combination of methodologies for providing the detail he/she needs for particular applications. Taylor & Francis 2015-03-05 Article PeerReviewed Gillis, Richard B., Rowe, Arthur J., Adams, Gary G. and Harding, Stephen E. (2015) A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology. Biotechnology and Genetic Engineering Reviews, 30 (2). pp. 142-157. ISSN 0264-8725 analytical ultracentrifugation SEC-MALS viscometry light scattering hydrodynamics biopolymer polydisperse http://www.tandfonline.com/doi/full/10.1080/02648725.2014.994870 doi:10.1080/02648725.2014.994870 doi:10.1080/02648725.2014.994870 |
| spellingShingle | analytical ultracentrifugation SEC-MALS viscometry light scattering hydrodynamics biopolymer polydisperse Gillis, Richard B. Rowe, Arthur J. Adams, Gary G. Harding, Stephen E. A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title | A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title_full | A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title_fullStr | A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title_full_unstemmed | A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title_short | A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| title_sort | review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology |
| topic | analytical ultracentrifugation SEC-MALS viscometry light scattering hydrodynamics biopolymer polydisperse |
| url | https://eprints.nottingham.ac.uk/42765/ https://eprints.nottingham.ac.uk/42765/ https://eprints.nottingham.ac.uk/42765/ |