Iron(II) catalyzed hydrophosphination of isocyanates
The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R],...
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| Format: | Article |
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Wiley-VCH Verlag
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41735/ |
| _version_ | 1848796341385297920 |
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| author | Sharpe, Helen R. Geer, Ana M. Lewis, William Blake, Alexander J. Kays, Deborah L. |
| author_facet | Sharpe, Helen R. Geer, Ana M. Lewis, William Blake, Alexander J. Kays, Deborah L. |
| author_sort | Sharpe, Helen R. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low-coordinate nature of the iron(II) centres whose inherent electron deficiency enables a Lewis-acid mechanism in which a combination of the steric pocket of the metal centre and substrate size determines the reaction products and regioselectivity. |
| first_indexed | 2025-11-14T19:46:26Z |
| format | Article |
| id | nottingham-41735 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:46:26Z |
| publishDate | 2017 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-417352020-05-04T18:42:07Z https://eprints.nottingham.ac.uk/41735/ Iron(II) catalyzed hydrophosphination of isocyanates Sharpe, Helen R. Geer, Ana M. Lewis, William Blake, Alexander J. Kays, Deborah L. The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low-coordinate nature of the iron(II) centres whose inherent electron deficiency enables a Lewis-acid mechanism in which a combination of the steric pocket of the metal centre and substrate size determines the reaction products and regioselectivity. Wiley-VCH Verlag 2017-04-18 Article PeerReviewed Sharpe, Helen R., Geer, Ana M., Lewis, William, Blake, Alexander J. and Kays, Deborah L. (2017) Iron(II) catalyzed hydrophosphination of isocyanates. Angewandte Chemie International Edition, 56 (17). pp. 4845-4848. ISSN 1521-3773 Hydrophosphination Iron Isocyanates m-terphenyl ligands Homogeneous catalysis http://onlinelibrary.wiley.com/doi/10.1002/anie.201701051/abstract doi:10.1002/anie.201701051 doi:10.1002/anie.201701051 |
| spellingShingle | Hydrophosphination Iron Isocyanates m-terphenyl ligands Homogeneous catalysis Sharpe, Helen R. Geer, Ana M. Lewis, William Blake, Alexander J. Kays, Deborah L. Iron(II) catalyzed hydrophosphination of isocyanates |
| title | Iron(II) catalyzed hydrophosphination of isocyanates |
| title_full | Iron(II) catalyzed hydrophosphination of isocyanates |
| title_fullStr | Iron(II) catalyzed hydrophosphination of isocyanates |
| title_full_unstemmed | Iron(II) catalyzed hydrophosphination of isocyanates |
| title_short | Iron(II) catalyzed hydrophosphination of isocyanates |
| title_sort | iron(ii) catalyzed hydrophosphination of isocyanates |
| topic | Hydrophosphination Iron Isocyanates m-terphenyl ligands Homogeneous catalysis |
| url | https://eprints.nottingham.ac.uk/41735/ https://eprints.nottingham.ac.uk/41735/ https://eprints.nottingham.ac.uk/41735/ |