Minocycline hepatotoxicity: clinical characterization and identification of HLA-B∗ 35:02 as a risk factor

Minocycline hepatotoxicity: clinical characterization and identification of HLA-B∗ 35:02 as a risk factor

Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline DILI in a well-phenotyped cohort of patients. Methods: Caucasian patients with minocycline DILI underwent genome-wide...

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Bibliographic Details
Main Authors: Urban, Thomas Jacob, Nicoletti, Paola, Chalasani, Naga, Serrano, Jose, Stolz, Andrew, Daly, Ann K., Aithal, Guruprasad P., Dillon, John F., Navarro, Victor, Odin, Joseph, Barnhart, Huiman X., Ostrov, David, Long, Nanye, Cirulli, Elizabeth Theresa, Watkins, Paul Brent, Fontana, Robert John
Format: Article
Published: Elsevier 2017
Subjects:
Drug induced liver injury
Single nucleotide polymorphism
Genetic association
Autoimmunity
Human leukocyte antigen
Online Access:https://eprints.nottingham.ac.uk/41683/

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https://eprints.nottingham.ac.uk/41683/

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