Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia
This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised o...
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| Format: | Article |
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Hindawi Publishing Corporation
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41589/ |
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| author | Gaffney, Christopher J. Mansell, Peter Stephens, Francis B. MacDonald, Ian A. Tsintzas, Kostas |
| author_facet | Gaffney, Christopher J. Mansell, Peter Stephens, Francis B. MacDonald, Ian A. Tsintzas, Kostas |
| author_sort | Gaffney, Christopher J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0 0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P < 0 05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P < 0 01), which was accompanied by a lower blood lactate response (P < 0 05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization. |
| first_indexed | 2025-11-14T19:45:56Z |
| format | Article |
| id | nottingham-41589 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:56Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-415892020-05-04T18:47:31Z https://eprints.nottingham.ac.uk/41589/ Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia Gaffney, Christopher J. Mansell, Peter Stephens, Francis B. MacDonald, Ian A. Tsintzas, Kostas This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0 0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P < 0 05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P < 0 01), which was accompanied by a lower blood lactate response (P < 0 05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization. Hindawi Publishing Corporation 2017-05-29 Article PeerReviewed Gaffney, Christopher J., Mansell, Peter, Stephens, Francis B., MacDonald, Ian A. and Tsintzas, Kostas (2017) Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia. Journal of Diabetes Research, 2017 . 8248725/1-8248725/8. ISSN 2314-6753 Non-obese Type 2 diabetes Exercise Cycling https://www.hindawi.com/journals/jdr/2017/8248725/ doi:10.1155/2017/8248725 doi:10.1155/2017/8248725 |
| spellingShingle | Non-obese Type 2 diabetes Exercise Cycling Gaffney, Christopher J. Mansell, Peter Stephens, Francis B. MacDonald, Ian A. Tsintzas, Kostas Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title | Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title_full | Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title_fullStr | Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title_full_unstemmed | Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title_short | Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| title_sort | exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia |
| topic | Non-obese Type 2 diabetes Exercise Cycling |
| url | https://eprints.nottingham.ac.uk/41589/ https://eprints.nottingham.ac.uk/41589/ https://eprints.nottingham.ac.uk/41589/ |