IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation
We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression...
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/41582/ |
| _version_ | 1848796308051066880 |
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| author | Penha, Rafael Higgins, John Mutamba, Shilla Barrow, Paul Mahida, Yashwant R. Foster, Neil |
| author_facet | Penha, Rafael Higgins, John Mutamba, Shilla Barrow, Paul Mahida, Yashwant R. Foster, Neil |
| author_sort | Penha, Rafael |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 β, which functions via IL-36R induced rapid and significant (P < 0.05) proliferation of CD4+ lymphocytes, within 48 h. IL-36R expression was also maintained on the surface of circulating CD4+ lymphocytes which enter the intestinal lamina propria.
In conclusion our study is the first to show that (1) all human blood lymphocytes express IL-36R; (2) IL-36R expression is maintained by circulating CD4+ lymphocytes which enter the intestinal lamina propria and (3) IL-36R/IL-36 β induces rapid CD4 lymphocyte proliferation. The possible significance of these results in the context of human disease is discussed. |
| first_indexed | 2025-11-14T19:45:55Z |
| format | Article |
| id | nottingham-41582 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:45:55Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-415822020-05-04T18:08:56Z https://eprints.nottingham.ac.uk/41582/ IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation Penha, Rafael Higgins, John Mutamba, Shilla Barrow, Paul Mahida, Yashwant R. Foster, Neil We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 β, which functions via IL-36R induced rapid and significant (P < 0.05) proliferation of CD4+ lymphocytes, within 48 h. IL-36R expression was also maintained on the surface of circulating CD4+ lymphocytes which enter the intestinal lamina propria. In conclusion our study is the first to show that (1) all human blood lymphocytes express IL-36R; (2) IL-36R expression is maintained by circulating CD4+ lymphocytes which enter the intestinal lamina propria and (3) IL-36R/IL-36 β induces rapid CD4 lymphocyte proliferation. The possible significance of these results in the context of human disease is discussed. Elsevier 2016-09-30 Article PeerReviewed Penha, Rafael, Higgins, John, Mutamba, Shilla, Barrow, Paul, Mahida, Yashwant R. and Foster, Neil (2016) IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Cytokine, 85 . pp. 18-25. ISSN 1096-0023 IL-36; IL-36R; Human; Lymphocyte https://doi.org/10.1016/j.cyto.2016.05.023 doi:10.1016/j.cyto.2016.05.023 doi:10.1016/j.cyto.2016.05.023 |
| spellingShingle | IL-36; IL-36R; Human; Lymphocyte Penha, Rafael Higgins, John Mutamba, Shilla Barrow, Paul Mahida, Yashwant R. Foster, Neil IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title | IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title_full | IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title_fullStr | IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title_full_unstemmed | IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title_short | IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation |
| title_sort | il-36 receptor is expressed by human blood and intestinal t lymphocytes and is dose–dependently activated via il-36β and induces cd4+ lymphocyte proliferation |
| topic | IL-36; IL-36R; Human; Lymphocyte |
| url | https://eprints.nottingham.ac.uk/41582/ https://eprints.nottingham.ac.uk/41582/ https://eprints.nottingham.ac.uk/41582/ |