Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women
OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue. PATIENTS AND METHODS: T...
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| Format: | Article |
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Verduci Editore
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41529/ |
| _version_ | 1848796295792164864 |
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| author | Alshammari, G. Khan, Raheela Brameld, John M. Amer, Saad A. Lomax, Michael A. |
| author_facet | Alshammari, G. Khan, Raheela Brameld, John M. Amer, Saad A. Lomax, Michael A. |
| author_sort | Alshammari, G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue.
PATIENTS AND METHODS: Two groups of women were investigated, those diagnosed with PCOS (n = 8) and age and BMI-matched normal women (n = 12). Their age was between 20-45 years and all subjects were apparently healthy and did not take any medications. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR.
RESULTS: There were no differences between obese patients and obese PCOS in levels of adipocytokines.
CONCLUSIONS: There were no effects of PCOS on the expression of any of the adipocytokines genes measured in subcutaneous adipose tissue. |
| first_indexed | 2025-11-14T19:45:43Z |
| format | Article |
| id | nottingham-41529 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:43Z |
| publishDate | 2017 |
| publisher | Verduci Editore |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-415292020-05-04T18:38:31Z https://eprints.nottingham.ac.uk/41529/ Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women Alshammari, G. Khan, Raheela Brameld, John M. Amer, Saad A. Lomax, Michael A. OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue. PATIENTS AND METHODS: Two groups of women were investigated, those diagnosed with PCOS (n = 8) and age and BMI-matched normal women (n = 12). Their age was between 20-45 years and all subjects were apparently healthy and did not take any medications. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR. RESULTS: There were no differences between obese patients and obese PCOS in levels of adipocytokines. CONCLUSIONS: There were no effects of PCOS on the expression of any of the adipocytokines genes measured in subcutaneous adipose tissue. Verduci Editore 2017-03-23 Article PeerReviewed Alshammari, G., Khan, Raheela, Brameld, John M., Amer, Saad A. and Lomax, Michael A. (2017) Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21 (5). pp. 1099-1105. ISSN 2284-0729 Polycystic ovary syndrome Insulin resistance Inflammation http://www.europeanreview.org/article/12334 |
| spellingShingle | Polycystic ovary syndrome Insulin resistance Inflammation Alshammari, G. Khan, Raheela Brameld, John M. Amer, Saad A. Lomax, Michael A. Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title | Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title_full | Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title_fullStr | Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title_full_unstemmed | Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title_short | Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| title_sort | gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women |
| topic | Polycystic ovary syndrome Insulin resistance Inflammation |
| url | https://eprints.nottingham.ac.uk/41529/ https://eprints.nottingham.ac.uk/41529/ |