Long receptor residence time of C26 contributes to super agonist activity at the human β2 adrenoceptor

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Long receptor residence time of C26 contributes to super agonist activity at the human β2 adrenoceptor

Super agonists produce greater functional responses than endogenous agonists in the same assay, and their unique pharmacology is the subject of increasing interest and debate. We propose that receptor residence time and the duration of receptor signaling contribute to the pharmacology of super agoni...

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Bibliographic Details
Main Authors:	Rosethorne, Elizabeth M., Bradley, Michelle E., Gherbi, Karolina, Sykes, David A., Sattikar, Afrah, Wright, John D., Renard, Emilie, Trifilieff, A., Fairhurst, Robin A., Charlton, Steven J.
Format:	Article
Published:	American Society for Pharmacology and Experimental Therapeutics (ASPET) 2016
Online Access:	https://eprints.nottingham.ac.uk/41456/

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