Dynamics of 5-carboxylcytosine during hepatic differentiation: potential general role for active demethylation by DNA repair in lineage specification

Dynamics of 5-carboxylcytosine during hepatic differentiation: potential general role for active demethylation by DNA repair in lineage specification

Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression. TET proteins oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Both 5fC and 5caC can be r...

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Bibliographic Details
Main Authors: Lewis, Lara C., Lo, Peggy Cho Kiu, Foster, Jeremy M., Dai, Nan, Correa, Ivan R., Durczak, Paulina M., Duncan, Gary, Ramsawhook, Ashley, Aithal, Guruprasad P., Denning, Chris, Hannan, Nicholas R.F., Ruzov, Alexey
Format: Article
Published: Taylor & Francis 2017
Subjects:
DNA methylation; 5-hydroxymethylcytosine; 5-carboxylcytosine; TET1/2/3 proteins; human pluripotent stem cells; hepatic differentiation; hepatocytes; definitive endoderm specification; immunohistochemistry
Online Access:https://eprints.nottingham.ac.uk/41227/

Internet

https://eprints.nottingham.ac.uk/41227/

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