Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2

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Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2

The use of γ-Al2O3 as a heterogeneous catalyst in scCO2, has be successfully applied to the amination of alcohols for the synthesis of N-alkylated heterocycles. The optimal reaction conditions (temperature and substrate flow rate) were determined using an automated self-optimising reactor, resulting...

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Bibliographic Details
Main Authors:	Streng, Emelia S., Lee, Darren S., George, Michael W., Poliakoff, Martyn
Format:	Article
Published:	Beilstein-Institut 2017
Subjects:	Continuous flow; heterocycle; N-alkylation; self-optimisation; supercritical CO2
Online Access:	https://eprints.nottingham.ac.uk/41185/

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