The amino-terminal domain of the androgen receptor co-opts extracellular signal-regulated kinase (ERK) docking sites in ELK1 protein to induce sustained gene activation that supports prostate cancer cell growth
The ETS domain transcription factor ELK1 is in a repressive association with growth genes and is transiently activated through phosphorylation by ERK1/2. In prostate cancer (PCa) cells the androgen receptor (AR) is recruited by ELK1, via its amino-terminal domain (A/B), as a transcriptional co-activ...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Biochemistry and Molecular Biology
2016
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/41159/ |