NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo

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NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo

Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically-induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth. We have previously proposed that axonal NMNAT2 primarily promotes axon survival by maintaining low levels of its substrate NMN,...

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Bibliographic Details
Main Authors:	Di Stefano, Michele, Loreto, Andrea, Orsomando, Giuseppe, Mori, Valerio, Zamporlini, Federica, Hulse, Richard P., Webster, Jamie, Donaldson, Lucy F., Gering, Martin, Raffaelli, Nadia, Coleman, Michael P., Gilley, Jonathan, Conforti, Laura
Format:	Article
Published:	Elsevier (Cell Press) 2017
Subjects:	axon degeneration; Wallerian degeneration; NMNAT2; NMNAT; NMN; NAD; NMN deamidase; WLDs; SARM1; neurodegeneration
Online Access:	https://eprints.nottingham.ac.uk/40868/

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