NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo

NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo

Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically-induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth. We have previously proposed that axonal NMNAT2 primarily promotes axon survival by maintaining low levels of its substrate NMN,...

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Bibliographic Details
Main Authors: Di Stefano, Michele, Loreto, Andrea, Orsomando, Giuseppe, Mori, Valerio, Zamporlini, Federica, Hulse, Richard P., Webster, Jamie, Donaldson, Lucy F., Gering, Martin, Raffaelli, Nadia, Coleman, Michael P., Gilley, Jonathan, Conforti, Laura
Format: Article
Published: Elsevier (Cell Press) 2017
Subjects:
axon degeneration; Wallerian degeneration; NMNAT2; NMNAT; NMN; NAD; NMN deamidase; WLDs; SARM1; neurodegeneration
Online Access:https://eprints.nottingham.ac.uk/40868/

Internet

https://eprints.nottingham.ac.uk/40868/

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