Alkylation of staurosporine to derive a kinase probe for fluorescence applications

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Alkylation of staurosporine to derive a kinase probe for fluorescence applications

The natural product staurosporine is a high-affinity inhibitor of nearly all mammalian protein kinases.The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation of the 4’-methylamine of the sugar moiety of...

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Bibliographic Details
Main Authors:	Disney, Alexander J.M., Kellam, Barrie, Dekker, Lodewijk V.
Format:	Article
Published:	Wiley-VCH Verlag 2016
Online Access:	https://eprints.nottingham.ac.uk/40837/

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