Canine idiopathic chronic hepatitis
Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis. Clinical signs are vague and non-specific, but there are known breed, age and g...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40734/ |
| _version_ | 1848796128202457088 |
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| author | Bexfield, Nicholas |
| author_facet | Bexfield, Nicholas |
| author_sort | Bexfield, Nicholas |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis.
Clinical signs are vague and non-specific, but there are known breed, age and gender predispositions.
Results of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis.
Management involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet.
The prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension |
| first_indexed | 2025-11-14T19:43:03Z |
| format | Article |
| id | nottingham-40734 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:43:03Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-407342020-05-04T18:48:21Z https://eprints.nottingham.ac.uk/40734/ Canine idiopathic chronic hepatitis Bexfield, Nicholas Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis. Clinical signs are vague and non-specific, but there are known breed, age and gender predispositions. Results of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis. Management involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet. The prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension Elsevier 2017-05-31 Article PeerReviewed Bexfield, Nicholas (2017) Canine idiopathic chronic hepatitis. Veterinary Clinics of North America: Small Animal Practice, 47 (3). pp. 645-663. ISSN 1878-1306 Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis http://www.sciencedirect.com/science/article/pii/S0195561616301589 doi:10.1016/j.cvsm.2016.11.012 doi:10.1016/j.cvsm.2016.11.012 |
| spellingShingle | Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis Bexfield, Nicholas Canine idiopathic chronic hepatitis |
| title | Canine idiopathic chronic hepatitis |
| title_full | Canine idiopathic chronic hepatitis |
| title_fullStr | Canine idiopathic chronic hepatitis |
| title_full_unstemmed | Canine idiopathic chronic hepatitis |
| title_short | Canine idiopathic chronic hepatitis |
| title_sort | canine idiopathic chronic hepatitis |
| topic | Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis |
| url | https://eprints.nottingham.ac.uk/40734/ https://eprints.nottingham.ac.uk/40734/ https://eprints.nottingham.ac.uk/40734/ |