Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound b1-adrenergic receptor
Comparisons between structures of the b1-adrenergic receptor (AR) bound to either agonists, partial agonists, or weak partial agonists led to the proposal that rotamer changes of Ser5.46, coupled to a contraction of the binding pocket, are sufficient to increase the probability of receptor activatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
ASPET
2015
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| Online Access: | https://eprints.nottingham.ac.uk/40727/ |