Salmeterol's extreme b2 selectivity is due to residues in both extracellular loops and transmembrane domains

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Salmeterol's extreme b2 selectivity is due to residues in both extracellular loops and transmembrane domains

Salmeterol is a long-acting b2-agonist, widely used as an inhaled treatment of asthma and chronic obstructive pulmonary disease. It has very high b2-affinity (log KD 28.95) and is very selective for the b2-adrenoceptor (1000-fold selectivity over the b1-adrenoceptor). This study used a mutagenesis a...

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Bibliographic Details
Main Authors:	Baker, Jillian G., Proudman, Richard G.W., Hill, Stephen J.
Format:	Article
Published:	American Society for Pharmacology and Experimental Therapeutics 2015
Online Access:	https://eprints.nottingham.ac.uk/40583/

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