Salmeterol's extreme b2 selectivity is due to residues in both extracellular loops and transmembrane domains
Salmeterol is a long-acting b2-agonist, widely used as an inhaled treatment of asthma and chronic obstructive pulmonary disease. It has very high b2-affinity (log KD 28.95) and is very selective for the b2-adrenoceptor (1000-fold selectivity over the b1-adrenoceptor). This study used a mutagenesis a...
| Main Authors: | , , |
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| Format: | Article |
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American Society for Pharmacology and Experimental Therapeutics
2015
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| Online Access: | https://eprints.nottingham.ac.uk/40583/ |