Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human 1-adrenoceptor

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Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human 1-adrenoceptor

The β1-adrenoceptor exists in two agonist conformations/states: 1) a high-affinity state where responses to catecholamines and other agonists (e.g., cimaterol) are potently inhibited by β1-adrenoceptor antagonists, and 2) a low-affinity secondary conformation where agonist responses, particularly CG...

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Bibliographic Details
Main Authors:	Baker, Jillian G., Proudman, Richard G.W., Hill, Stephen J.
Format:	Article
Published:	American Society for Pharmacology and Experimental Therapeutics 2014
Online Access:	https://eprints.nottingham.ac.uk/40552/

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