Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human 1-adrenoceptor
The β1-adrenoceptor exists in two agonist conformations/states: 1) a high-affinity state where responses to catecholamines and other agonists (e.g., cimaterol) are potently inhibited by β1-adrenoceptor antagonists, and 2) a low-affinity secondary conformation where agonist responses, particularly CG...
| Main Authors: | , , |
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| Format: | Article |
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American Society for Pharmacology and Experimental Therapeutics
2014
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| Online Access: | https://eprints.nottingham.ac.uk/40552/ |