Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

QR Code

Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

Background and Purpose: The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on the efficacy of two agonists at multipl...

Full description

Bibliographic Details
Main Authors:	Stoddart, Leigh A., Kellam, Barrie, Briddon, Stephen J., Hill, Stephen J.
Format:	Article
Published:	Wiley 2014
Online Access:	https://eprints.nottingham.ac.uk/40524/

Similar Items

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist
by: Stoddart, Leigh A., et al.
Published: (2015)

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells
by: Arruda, Maria Augusta, et al.
Published: (2017)

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
by: Corriden, Ross, et al.
Published: (2014)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes
by: Corriden, Ross, et al.
Published: (2013)

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers
by: Vernall, Andrea J., et al.
Published: (2013)

Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models
by: Ranganathan, Anirudh, et al.
Published: (2015)

Cost effectiveness of surveillance for GI cancers
by: Omidvari, A., et al.
Published: (2016)

Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor
by: Schembri, Luke S., et al.
Published: (2015)

Occurrence of Norovirus GI in green and red onion
by: Mohd Sahroni, Noor Hidayah, et al.
Published: (2011)

DiGi.Com: strategies for capturing market share
by: Adham, Khairul Akmaliah, et al.
Published: (2011)

DiGi Corporate Social Responsibility: A Case Study
by: Abdo, Lina Abdulmalek Saeed
Published: (2010)

Blind Channel Identification and Equalization for GI-less OFDM Systems
by: Al-ayyan, Faisal, et al.
Published: (2008)

DiGi not guaranteed to get 3G spectrum licence
Published: (2008)

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation
by: Headrick, J., et al.
Published: (2011)

Genome sequence survey of local isolated alkaliphilic bacillus sp. GI
by: Liew, Chong Wai, et al.
Published: (2005)

Development of novel fluorescent histamine H₁-receptor antagonists to study ligand-binding kinetics in living cells
by: Stoddart, Leigh A., et al.
Published: (2018)

Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925
by: Conroy, Sean, et al.
Published: (2018)

Blind channel equalization in GI-less OFDM systems using property restoral
by: Alayyan, F., et al.
Published: (2010)

Lipid based interfacial design of food emulsion for controlling thelipolysis progress of GI-track
by: Chen, Guanghua
Published: (2021)

Investigating cooperativity across adenosine A3 receptor homo- and hetero-oligomers
by: Groenewoud, N.J.A.
Published: (2019)

Factors affecting the anthelmintic efficacy of cysteine proteinases against GI nematodes and their formulation for use in ruminants
by: Luoga, Wenceslaus
Published: (2013)

Illuminating the life of the adenosine receptors: development and application of subtype-selective fluorescent probes for the study of the human A1 and A2A adenosine receptors in living cells
by: Comeo, Eleonora
Published: (2022)

Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics
by: Hothersall, J. Daniel, et al.
Published: (2017)

Leakage Detection in Galvanized Iron (GI) Pipelines Using Ensemble Empirical Mode Decomposition Analysis (EEMD)
by: Makeen, Mohd Amin, et al.
Published: (2014)

PFR model and GiT for landslide susceptibility mapping: a case study from Central Alborz, Iran
by: Jadda, Mehrnoosh, et al.
Published: (2011)

Using super resolution microscopy to investigate the role of actin in adenosine receptor organisation
by: Garlick, Evelyn
Published: (2023)

Tumor necrosis factor receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome
by: Fairclough, Lucy C., et al.
Published: (2015)

Web crippling strength of GI based cold- formed steel under high temperature: experimental and analytical modeling
by: Sam, Varun Sabu, et al.
Published: (2025)

A Glocalised National Narrative: A Siraya-based Discourse In The Tai-gi Puppet Play Blitzkrieg Siraya
by: Tenn , Nga-i
Published: (2014)

Role of adenosine receptors in mediating inflammatory cytokines in hyperglycemic muller cells / Selvakumar Mararajah
by: Selvakumar , Mararajah
Published: (2015)

Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
by: Yuliana, Nancy Dewi, et al.
Published: (2009)

Co-operative Governance Index (Co-opGI) and its application in credit co-operatives in Malaysia / Hayati Md. Salleh
by: Md. Salleh, Hayati
Published: (2011)

Predictive factors for mortality, recurrent bleeding and need for surgery in non-variceal upper gastrointestinal (GI) bleeding in correlation with rockall score
by: Noridah, Nordin
Published: (2008)

Measuring ligand concentration where it matters: Assessing the “micro pharmacokinetic/pharmacodynamics” of adenosine receptor ligands
by: Lochray, Jack
Published: (2022)

'A study on the service performance of "on-call-maintenance services" by DiGiCITY (M) Sdn Bhd.' / Mohd Izral Mohd Nazir
by: Mohd Nazir, Mohd Izral
Published: (2002)

Validation of in vitro glycaemic index (eGI) and glycaemic load (eGL) based on selected baked products, beverages, and canned foods
by: Sulung, Nur Khuraishah, et al.
Published: (2023)

Cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists
by: Wragg, Edward
Published: (2023)

Drug-like antagonists of P2Y receptors — from lead identification to drug development
by: Conroy, Sean, et al.
Published: (2016)

Factors that influence consumer behavior towards telecommunication operators: a case study at DiGi Shah Alam / Siti Fadilah Mohd Rusli
by: Mohd Rusli, Siti Fadilah
Published: (2015)