Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization
Background and Purpose: The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on the efficacy of two agonists at multipl...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Wiley
2014
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| Online Access: | https://eprints.nottingham.ac.uk/40524/ |