Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics

Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics

The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied using cAMP assays in recombinantly (CHO) and endogeno...

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Main Authors: Hothersall, J. Daniel, Guo, Dong, Sarda, Sunil, Sheppard, Robert J., Chen, Hongming, Keur, Wesley, Waring, Michael J., IJzerman, Adriaan P., Hill, Stephen J., Dale, Ian L., Rawlins, Philip B.
Format: Article
Published: ASPET 2017
Online Access:https://eprints.nottingham.ac.uk/40520/

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https://eprints.nottingham.ac.uk/40520/

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