Development of ssRNA for therapeutic gene knock-down

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Development of ssRNA for therapeutic gene knock-down

Work presented in this thesis shows how chemical modifications of ssRNAs can increase their nuclease resistance, resulting in potent gene inhibition. The first part of thesis describes how a range of chemical modifications were introduced into the ssRNAs to test their effect on oligonucleotide stabi...

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Bibliographic Details
Main Author:	Powalowska, Paulina Klaudyna
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Online Access:	https://eprints.nottingham.ac.uk/40508/

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