Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis

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Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis

Objectives. Interferon-β (IFN-β) is used in the treatment of multiple sclerosis (MS). IFN-β activation of signal transduction and activation of transcription (STAT)-4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN deficit in immune cells of MS patients, but data on...

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Bibliographic Details
Main Authors:	Tanasescu, Radu, Midgley, Angela, Robins, R. Adrian, Constantinescu, Cris S.
Format:	Article
Published:	Wiley 2016
Online Access:	https://eprints.nottingham.ac.uk/40258/

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