Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis
Objectives. Interferon-β (IFN-β) is used in the treatment of multiple sclerosis (MS). IFN-β activation of signal transduction and activation of transcription (STAT)-4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN deficit in immune cells of MS patients, but data on...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/40258/ |