The synthesis of ortho-fused cycloocta-2,5-dien-1-one cores and their derivatisation
Eight-membered rings are notoriously difficult to synthesise due to unfavourable transannular and conformational strain within the ring system. That being said, there are many biologically active natural products that contain such ring systems. For instance, potent anti-cancer compound Taxol®, has a...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English English |
| Published: |
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40164/ |