Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease

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Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10−4) in 35,962 independent samples using...

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Bibliographic Details
Main Authors:	Sims, Rebecca, van der Lee, Sven J., Naj, Adam C., Bellenguez, Céline, Badarinarayan, Nandini, Jakobsdottir, Johanna, Kunkle, Brian W., Boland, Anne, Raybould, Rachel, Bis, Josha C., Martin, Eden R., Grenier-Boley, Benjamin, Medway, Christopher, Brown, Kristelle, Braae, Anne, Lord, Jenny, Turton, James, Barber, Imelda S., Brookes, Keeley, Morgan, Kevin
Format:	Article
Published:	Nature Publishing Group 2017
Online Access:	https://eprints.nottingham.ac.uk/40053/

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