Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease

Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10−4) in 35,962 independent samples using...

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Bibliographic Details
Main Authors: Sims, Rebecca, van der Lee, Sven J., Naj, Adam C., Bellenguez, Céline, Badarinarayan, Nandini, Jakobsdottir, Johanna, Kunkle, Brian W., Boland, Anne, Raybould, Rachel, Bis, Josha C., Martin, Eden R., Grenier-Boley, Benjamin, Medway, Christopher, Brown, Kristelle, Braae, Anne, Lord, Jenny, Turton, James, Barber, Imelda S., Brookes, Keeley, Morgan, Kevin
Format: Article
Published: Nature Publishing Group 2017
Online Access:https://eprints.nottingham.ac.uk/40053/

Internet

https://eprints.nottingham.ac.uk/40053/

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