Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases

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Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases

Type I modular polyketide synthases (PKSs), responsible for the biosynthesis of many biologically active agents, possess a ketosynthase (KS) domain within each module to catalyze chain elongation. Acylation of the KS active site Cys residue is followed by transfer to malonyl-acyl carrier protein,...

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Bibliographic Details
Main Authors:	Jenner, Matthew, Afonso, José Pedro, Bailey, Hannah R., Frank, Sarah, Kampa, Annette, Piel, Jörn, Oldfield, Neil J.
Format:	Article
Published:	Wiley-VCH Verlag 2015
Online Access:	https://eprints.nottingham.ac.uk/39789/

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