Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases
Type I modular polyketide synthases (PKSs), responsible for the biosynthesis of many biologically active agents, possess a ketosynthase (KS) domain within each module to catalyze chain elongation. Acylation of the KS active site Cys residue is followed by transfer to malonyl-acyl carrier protein,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Wiley-VCH Verlag
2015
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| Online Access: | https://eprints.nottingham.ac.uk/39789/ |