Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice
Nutrition during pregnancy can impact on the susceptibility of the offspring to cardiovascular disease. Postnatal consumption of trans fatty acids (TFA), associated with partially hydrogenated vegetable oil (PHVO), increases the risk of atherosclerosis, while evidence for those trans fatty acids ass...
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Cambridge University Press
2017
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| Online Access: | https://eprints.nottingham.ac.uk/39655/ |
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| author | Salter, Andrew M. Langley-Evans, Simon C. Gates, Louise Lock, Adam L. Kraft, Jana |
| author_facet | Salter, Andrew M. Langley-Evans, Simon C. Gates, Louise Lock, Adam L. Kraft, Jana |
| author_sort | Salter, Andrew M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Nutrition during pregnancy can impact on the susceptibility of the offspring to cardiovascular disease. Postnatal consumption of trans fatty acids (TFA), associated with partially hydrogenated vegetable oil (PHVO), increases the risk of atherosclerosis, while evidence for those trans fatty acids associated with ruminant-derived dairy and meat remain equivocal. Here, we investigate the impact of maternal consumption of dietary PHVO (P) and ruminant milk fat (R) on the development of atherosclerosis in their offspring, using the transgenic apoE*3 Leiden mouse. Dams were fed either chow (C) or one of three high fat diets: a diet reflecting the saturated fatty acid content of a ‘Western’ diet (W) or one enriched with either P or R. Diets were fed during either pregnancy alone or pregnancy and lactation. Weaned offspring were then transferred to an atherogenic diet for twelve weeks. Atherosclerosis was assessed as lipid staining in cross-sections of the aorta. There was a significant effect of maternal diet during pregnancy on development of atherosclerosis (p=0.013) in the offspring with those born of mothers fed R or P during pregnancy displaying smaller lesions that those fed C or W. This was not associated with changes in total or lipoprotein cholesterol. Continuing to feed P during lactation increased atherosclerosis compared to that seen in offspring of dams fed P only during pregnancy (p<0.001). No such effect was seen in those from mothers fed R (p=0.596) or W (p=901). We conclude that dietary TFA have differing effects on cardiovascular risk at different stages of the lifecycle. |
| first_indexed | 2025-11-14T19:39:11Z |
| format | Article |
| id | nottingham-39655 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:39:11Z |
| publishDate | 2017 |
| publisher | Cambridge University Press |
| recordtype | eprints |
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| spelling | nottingham-396552024-08-15T15:21:36Z https://eprints.nottingham.ac.uk/39655/ Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice Salter, Andrew M. Langley-Evans, Simon C. Gates, Louise Lock, Adam L. Kraft, Jana Nutrition during pregnancy can impact on the susceptibility of the offspring to cardiovascular disease. Postnatal consumption of trans fatty acids (TFA), associated with partially hydrogenated vegetable oil (PHVO), increases the risk of atherosclerosis, while evidence for those trans fatty acids associated with ruminant-derived dairy and meat remain equivocal. Here, we investigate the impact of maternal consumption of dietary PHVO (P) and ruminant milk fat (R) on the development of atherosclerosis in their offspring, using the transgenic apoE*3 Leiden mouse. Dams were fed either chow (C) or one of three high fat diets: a diet reflecting the saturated fatty acid content of a ‘Western’ diet (W) or one enriched with either P or R. Diets were fed during either pregnancy alone or pregnancy and lactation. Weaned offspring were then transferred to an atherogenic diet for twelve weeks. Atherosclerosis was assessed as lipid staining in cross-sections of the aorta. There was a significant effect of maternal diet during pregnancy on development of atherosclerosis (p=0.013) in the offspring with those born of mothers fed R or P during pregnancy displaying smaller lesions that those fed C or W. This was not associated with changes in total or lipoprotein cholesterol. Continuing to feed P during lactation increased atherosclerosis compared to that seen in offspring of dams fed P only during pregnancy (p<0.001). No such effect was seen in those from mothers fed R (p=0.596) or W (p=901). We conclude that dietary TFA have differing effects on cardiovascular risk at different stages of the lifecycle. Cambridge University Press 2017-01-06 Article PeerReviewed Salter, Andrew M., Langley-Evans, Simon C., Gates, Louise, Lock, Adam L. and Kraft, Jana (2017) Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice. British Journal of Nutrition . ISSN 1475-2662 (In Press) Trans fatty acid maternal diet programming atherosclerosis |
| spellingShingle | Trans fatty acid maternal diet programming atherosclerosis Salter, Andrew M. Langley-Evans, Simon C. Gates, Louise Lock, Adam L. Kraft, Jana Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title | Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title_full | Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title_fullStr | Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title_full_unstemmed | Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title_short | Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice |
| title_sort | fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein e*3 leiden mice |
| topic | Trans fatty acid maternal diet programming atherosclerosis |
| url | https://eprints.nottingham.ac.uk/39655/ |