Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI
Background Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi-automatic imaging metric of ascending colonic wall m...
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/39606/ |
| _version_ | 1848795874921021440 |
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| author | Hoad, Caroline Menys, A. Garsed, Klara Marciani, Luca Hamy, Valentin Murray, Kathryn Costigan, Carolyn Atkinson, D. Major, Giles Spiller, Robin C. Taylor, S. Gowland, Penny A. |
| author_facet | Hoad, Caroline Menys, A. Garsed, Klara Marciani, Luca Hamy, Valentin Murray, Kathryn Costigan, Carolyn Atkinson, D. Major, Giles Spiller, Robin C. Taylor, S. Gowland, Penny A. |
| author_sort | Hoad, Caroline |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi-automatic imaging metric of ascending colonic wall movement, using image registration techniques.
Methods
Cine balanced turbo field echo MRI images of ascending colonic motility were acquired over 2 min from 23 healthy volunteers (HVs) at baseline and following two different macrogol stimulus drinks (11 HVs drank 1 L and 12 HVs drank 2 L). Motility metrics derived from large scale geometric and small scale pixel movement parameters following image registration were developed using the post ingestion data and compared to observer grading of wall motion. Inter and intra-observer variability in the highest correlating metric was assessed using Bland–Altman analysis calculated from two separate observations on a subset of data.
Key Results
All the metrics tested showed significant correlation with the observer rating scores. Line analysis (LA) produced the highest correlation coefficient of 0.74 (95% CI: 0.55–0.86), p < 0.001 (Spearman Rho). Bland–Altman analysis of the inter- and intra-observer variability for the LA metric, showed almost zero bias and small limits of agreement between observations (−0.039 to 0.052 intra-observer and −0.051 to 0.054 inter-observer, range of measurement 0–0.353).
Conclusions & Inferences
The LA index of colonic motility derived from cine MRI registered data provides a quick, accurate and non-invasive method to detect wall motion within the ascending colon following a colonic stimulus in the form of a macrogol drink. |
| first_indexed | 2025-11-14T19:39:02Z |
| format | Article |
| id | nottingham-39606 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:39:02Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-396062020-05-04T20:03:27Z https://eprints.nottingham.ac.uk/39606/ Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI Hoad, Caroline Menys, A. Garsed, Klara Marciani, Luca Hamy, Valentin Murray, Kathryn Costigan, Carolyn Atkinson, D. Major, Giles Spiller, Robin C. Taylor, S. Gowland, Penny A. Background Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi-automatic imaging metric of ascending colonic wall movement, using image registration techniques. Methods Cine balanced turbo field echo MRI images of ascending colonic motility were acquired over 2 min from 23 healthy volunteers (HVs) at baseline and following two different macrogol stimulus drinks (11 HVs drank 1 L and 12 HVs drank 2 L). Motility metrics derived from large scale geometric and small scale pixel movement parameters following image registration were developed using the post ingestion data and compared to observer grading of wall motion. Inter and intra-observer variability in the highest correlating metric was assessed using Bland–Altman analysis calculated from two separate observations on a subset of data. Key Results All the metrics tested showed significant correlation with the observer rating scores. Line analysis (LA) produced the highest correlation coefficient of 0.74 (95% CI: 0.55–0.86), p < 0.001 (Spearman Rho). Bland–Altman analysis of the inter- and intra-observer variability for the LA metric, showed almost zero bias and small limits of agreement between observations (−0.039 to 0.052 intra-observer and −0.051 to 0.054 inter-observer, range of measurement 0–0.353). Conclusions & Inferences The LA index of colonic motility derived from cine MRI registered data provides a quick, accurate and non-invasive method to detect wall motion within the ascending colon following a colonic stimulus in the form of a macrogol drink. Wiley 2016-03 Article PeerReviewed Hoad, Caroline, Menys, A., Garsed, Klara, Marciani, Luca, Hamy, Valentin, Murray, Kathryn, Costigan, Carolyn, Atkinson, D., Major, Giles, Spiller, Robin C., Taylor, S. and Gowland, Penny A. (2016) Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI. Neurogastroenterology and Motility, 28 (3). pp. 327-335. ISSN 1365-2982 ascending colon; cine MRI; imaging metric; motility http://onlinelibrary.wiley.com/doi/10.1111/nmo.12727/abstract doi:10.1111/nmo.12727 doi:10.1111/nmo.12727 |
| spellingShingle | ascending colon; cine MRI; imaging metric; motility Hoad, Caroline Menys, A. Garsed, Klara Marciani, Luca Hamy, Valentin Murray, Kathryn Costigan, Carolyn Atkinson, D. Major, Giles Spiller, Robin C. Taylor, S. Gowland, Penny A. Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title | Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title_full | Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title_fullStr | Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title_full_unstemmed | Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title_short | Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI |
| title_sort | colon wall motility: comparison of novel quantitative semi-automatic measurements using cine mri |
| topic | ascending colon; cine MRI; imaging metric; motility |
| url | https://eprints.nottingham.ac.uk/39606/ https://eprints.nottingham.ac.uk/39606/ https://eprints.nottingham.ac.uk/39606/ |