Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis

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Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis

There is currently no ideal radiotracer for imaging protein synthesis rate (PSR) by positron emission tomography (PET). Existing fluorine-18 labelled amino acid-based radiotracers predominantly visualize amino acid transporter processes, and in many cases they are not incorporated into nascent prote...

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Bibliographic Details
Main Authors:	Betts, Helen M., Sephton, Selena Milicevic, Tong, Carmen, Awais, Ramla, Hill, Philip J., Perkins, A.C., Aigbirhio, Franklin I.
Format:	Article
Published:	American Chemical Society 2016
Subjects:	Positron emission tomography; protein synthesis; puromycin; fluorine-18
Online Access:	https://eprints.nottingham.ac.uk/39443/

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