Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes

Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes

Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulting in manganism, a condition with clinical symptom...

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Bibliographic Details
Main Authors: Tarale, Prashant, Sivanesan, Saravanadevi, Daiwile, Atul P., Stöger, Reinhard, Bafana, Amit, Naoghare, Pravin K., Parmar, Devendra, Chakrabarti, Tapan, Kannan, Krishnamurthi
Format: Article
Published: Springer 2016
Subjects:
DNA methylation
Manganese
Epigenetics
Parkinson’s disease
WGBS
Online Access:https://eprints.nottingham.ac.uk/39241/

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https://eprints.nottingham.ac.uk/39241/

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