Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?
Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the recent re-discovery of its presence in adult human...
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| Format: | Article |
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Lippincott, Williams & Wilkins
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38887/ |
| _version_ | 1848795713288273920 |
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| author | Aldiss, Peter Budge, Helen Symonds, Michael E. |
| author_facet | Aldiss, Peter Budge, Helen Symonds, Michael E. |
| author_sort | Aldiss, Peter |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the recent re-discovery of its presence in adult humans has led to huge interest in the role that it may play in modulating cardiometabolic health. Interestingly, as with maintenance of thermal homeostasis, the total amount and metabolic activity of BAT is modulated by sex and biological age. In this short commentary we discuss the recent finding that core-body temperature is reduced in women post-menopause, a period when excess adiposity and increased risk of cardiometabolic disease is evident and postulate that alterations in sex hormones downregulated the thermogenic activity of BAT cold contribute to this deleterious phenotype. |
| first_indexed | 2025-11-14T19:36:27Z |
| format | Article |
| id | nottingham-38887 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:36:27Z |
| publishDate | 2016 |
| publisher | Lippincott, Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-388872020-05-04T19:59:38Z https://eprints.nottingham.ac.uk/38887/ Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? Aldiss, Peter Budge, Helen Symonds, Michael E. Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the recent re-discovery of its presence in adult humans has led to huge interest in the role that it may play in modulating cardiometabolic health. Interestingly, as with maintenance of thermal homeostasis, the total amount and metabolic activity of BAT is modulated by sex and biological age. In this short commentary we discuss the recent finding that core-body temperature is reduced in women post-menopause, a period when excess adiposity and increased risk of cardiometabolic disease is evident and postulate that alterations in sex hormones downregulated the thermogenic activity of BAT cold contribute to this deleterious phenotype. Lippincott, Williams & Wilkins 2016-12 Article PeerReviewed Aldiss, Peter, Budge, Helen and Symonds, Michael E. (2016) Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? Cardiovascular Endocrinology, 5 (4). pp. 155-156. ISSN 2162-688X https://doi.org/10.1097/XCE.0000000000000089 doi:10.1097/XCE.0000000000000089 doi:10.1097/XCE.0000000000000089 |
| spellingShingle | Aldiss, Peter Budge, Helen Symonds, Michael E. Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title | Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title_full | Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title_fullStr | Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title_full_unstemmed | Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title_short | Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| title_sort | is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? |
| url | https://eprints.nottingham.ac.uk/38887/ https://eprints.nottingham.ac.uk/38887/ https://eprints.nottingham.ac.uk/38887/ |