Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke
The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral art...
| Main Authors: | , , , , , |
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| Format: | Article |
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SAGE
2017
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| Online Access: | https://eprints.nottingham.ac.uk/38803/ |
| _version_ | 1848795694419148800 |
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| author | Ahmed, Jewel Dwyer, Dominic E. Farr, Tracy D. Harrison, David J. Dunnett, Stephen B. Trueman, Rebecca C. |
| author_facet | Ahmed, Jewel Dwyer, Dominic E. Farr, Tracy D. Harrison, David J. Dunnett, Stephen B. Trueman, Rebecca C. |
| author_sort | Ahmed, Jewel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients. |
| first_indexed | 2025-11-14T19:36:09Z |
| format | Article |
| id | nottingham-38803 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:36:09Z |
| publishDate | 2017 |
| publisher | SAGE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-388032020-05-04T18:31:30Z https://eprints.nottingham.ac.uk/38803/ Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke Ahmed, Jewel Dwyer, Dominic E. Farr, Tracy D. Harrison, David J. Dunnett, Stephen B. Trueman, Rebecca C. The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients. SAGE 2017-01-06 Article PeerReviewed Ahmed, Jewel, Dwyer, Dominic E., Farr, Tracy D., Harrison, David J., Dunnett, Stephen B. and Trueman, Rebecca C. (2017) Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism, 37 (3). pp. 755-761. ISSN 1559-7016 Animal Models; Behavior (rodent); Experimental; Focal Ischemia; Stroke http://journals.sagepub.com/doi/full/10.1177/0271678X16684141 doi:10.1177/0271678X16684141 doi:10.1177/0271678X16684141 |
| spellingShingle | Animal Models; Behavior (rodent); Experimental; Focal Ischemia; Stroke Ahmed, Jewel Dwyer, Dominic E. Farr, Tracy D. Harrison, David J. Dunnett, Stephen B. Trueman, Rebecca C. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title | Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title_full | Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title_fullStr | Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title_full_unstemmed | Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title_short | Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| title_sort | lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke |
| topic | Animal Models; Behavior (rodent); Experimental; Focal Ischemia; Stroke |
| url | https://eprints.nottingham.ac.uk/38803/ https://eprints.nottingham.ac.uk/38803/ https://eprints.nottingham.ac.uk/38803/ |