Structural elements of an NRPS cyclization domain and its intermodule docking domain

QR Code

Structural elements of an NRPS cyclization domain and its intermodule docking domain

Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F. A cyclization domain of EpoB (Cy) assembles the thiazole functionality from an acetyl group and l-cysteine via con...

Full description

Bibliographic Details
Main Authors:	Dowling, Daniel P., Kung, Yan, Croft, Anna K., Taghizadeh, Koli, Kelly, Wendy L., Walsh, Christopher T., Drennan, Catherine L.
Format:	Article
Published:	National Academy of Sciences 2016
Subjects:	crystal strcuture molecular dynamics epithilone natural product
Online Access:	https://eprints.nottingham.ac.uk/38671/

Similar Items

Time-domain analysis of intermodulation distortion of closed-loop Class D amplifiers
by: Yu, J., et al.
Published: (2012)

Molecular analysis of condensation domain in non-ribosomal peptide synthetase (NRPS) gene of Ganoderma boninense
by: Shokrollahi, Neda, et al.
Published: (2018)

Crystallization and characterization of struvite crystals through gel growth technique
by: Salsabili, Ahmad
Published: (2017)

Crystallographic analysis of ground- and space-grown thermostable T1 lipase crystal
by: Mohamad Aris, Sayangku Nor Ariati
Published: (2013)

Using the higdon operator for the dual phase velocity boundary and the simulation of intermodulation
by: Ludeking, L., et al.
Published: (2015)

(N-Benzyl-N-isopropyldithiocarbamato)-chloridodiphenyltin(IV)
by: Abdul Muthalib, Amirah Faizah, et al.
Published: (2010)

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one
by: Ee, Gwendoline Cheng Lian, et al.
Published: (2010)

Cyclization vs. Cyclization/Dimerization in o-Amidostilbene Radical Cation Cascade Reactions: the Amide question
by: Chin , Hui Kee, et al.
Published: (2011)

Crystal Growth and Molecular Crystal Growth Modification
by: Jones, Franca, et al.
Published: (2012)

The structure of and origin of nodular chromite from the Troodos ophiolite, Cyprus, revealed using high-resolution X-ray computed tomography and electron backscatter diffraction
by: Prichard, H., et al.
Published: (2015)

Sulfonylative and azidosulfonylative cyclizations by visible-light-photosensitization of sulfonyl azides in THF
by: Zhu, Shaoqun, et al.
Published: (2017)

Synthesis And Characterization Of New Series Of Liquid Crystalline Compounds Containing Azobenzene And Bisazobenzene Moieties
by: Abubakar Salisu, Abdulsalam
Published: (2009)

Fractionation of palm kernel oil by short path distillation
by: Ramli, Muhamad Roddy
Published: (2013)

Cyclization enhances function of linear anti-arthritic peptides
by: Ali, Marina, et al.
Published: (2014)

Frequency Domain
by: Chan, Felix, et al.
Published: (2020)

Time Domain and Frequency Domain Analysis for Truss Spar Platform
by: Montasir,, O.A.A, et al.
Published: (2010)

Development and analysis of spatial domain and transform domain watermarking technique
by: Chua, Kah Keong
Published: (2011)

Antiferromagnetic domain structure in tetragonal CuMnAs films: A picturebook of domains, domain walls and everything in between
by: Reimers, Sonka
Published: (2022)

In-situ diffraction studies on the crystallization and crystal growth in anodized TiO2 nanofibres
by: Low, It-Meng, et al.
Published: (2012)

Investigation into the effect of phosphonate inhibitors on barium sulfate precipitation
by: Jones, Franca, et al.
Published: (2002)

Crystallization Behavior of Palm Oil Blends and Palm Oil-Based Fluid Shortenings
by: Mat Sahri, Miskandar
Published: (2006)

Frequency Behavior of Quartz Crystal Microbalance In Contact With Selected Solutions
by: Baba, Zuraidah
Published: (2007)

Characterization and crystallization of W200R protease
by: Muhd Noor, Noor Dina
Published: (2012)

Design of photonic band gap aperture coupled fractal shape tri-band active antenna
by: Saeidi, Tale
Published: (2014)

Physical, structural and optical properties of willemite-based glass-ceramic doped with erbium oxide
by: Effendy, Nuraidayani
Published: (2017)

Intramolecular Oxidative Heck Cyclization: a Novel Pathwayto Cyclopentenones
by: Nguyen, Thanh Vinh
Published: (2008)

The Domain-general vs. Domain-specific Role of Metacognition in Arithmetic Achievements
by: Nigar, Naima
Published: (2023)

Islamic finance as domain
by: Mohd Tawil, Siti Fatimah, et al.
Published: (2011)

Cyberspace: the warfare domain
by: Songip, Ahmad Rahman, et al.
Published: (2013)

Image restoration techniques in spatial domain and frequency domains / Osamah Jasim Madhloom
by: Osamah Jasim, Madhloom
Published: (2017)

Domain decomposition preconditioners for discontinuous Galerkin methods for elliptic problems on complicated domains
by: Antonietti, Paola F., et al.
Published: (2014)

Domain Model Definition for Domain-Specific Rule Generation Using Variability Model
by: Mani, N., et al.
Published: (2018)

Domain bifurcation as a customisation and business intelligence strategy in domain-driven innovation
by: Meersman, Davor
Published: (2012)

Empirical analysis of Domain Ontology usage on the Web: eCommerce Domain in focus.
by: Ashraf, Jamshaid, et al.
Published: (2013)

STABILITY OF CLASSICAL FINITE-DIFFERENCE TIME-DOMAIN (FDTD) FORMULATION WITH NONLINEAR ELEMENTS—A NEW PERSPECTIVE - ABSTRACT
by: Kung, F., et al.
Published: (2003)

The role of the cysteine-rich domain and netrin-like domain of secreted frizzled-related protein 4 in angiogenesis inhibition in vitro
by: Longman, D., et al.
Published: (2012)

Video distortion measurement using psnr in wavelet domain
by: Mok, Y.L
Published: (2010)

Deriving domain specific requirement pattern for Collaborative Meeting and Appointment Scheduler Domain (CMASD)
by: Suhaizad, Farah Nur Atiqah, et al.
Published: (2016)

Performance analysis of SWOT suite toolkit on Inter-domain and Intra-domain Web of Things
by: Anuar, Nur Ameera, et al.
Published: (2017)

Time domain studies of Active Galactic Nuclei with the Square Kilometre Array
by: Bignall, Hayley, et al.
Published: (2015)