Structural elements of an NRPS cyclization domain and its intermodule docking domain
Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F. A cyclization domain of EpoB (Cy) assembles the thiazole functionality from an acetyl group and l-cysteine via con...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
National Academy of Sciences
2016
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/38671/ |