Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior
Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction. Recent studies have suggested that positive allosteric modulation of the M1 muscarinic acetylcholine receptor (mAChR) may provide a nov...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Pharmacology and Experimental Therapeutics
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38627/ |