GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors

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GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors

G protein-coupled receptors (GPCRs) are proteins of pharmaceutical importance, with over 30% of all drugs in clinical use targeting them. Increasing numbers of X-ray crystal (XRC) structures of GPCRs offer a wealth of data relating to ligand binding. For the β-adrenoceptors (β-ARs), XRC structures a...

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Bibliographic Details
Main Authors:	Emtage, Abigail L., Mistry, Shailesh N., Fischer, Peter M., Kellam, Barrie, Laughton, Charles A.
Format:	Article
Published:	Taylor and Francis 2016
Subjects:	GPCRs beta adrenergic receptor modelling docking active site pressurisation molecular dynamics protein flexibility
Online Access:	https://eprints.nottingham.ac.uk/38626/

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