GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors
G protein-coupled receptors (GPCRs) are proteins of pharmaceutical importance, with over 30% of all drugs in clinical use targeting them. Increasing numbers of X-ray crystal (XRC) structures of GPCRs offer a wealth of data relating to ligand binding. For the β-adrenoceptors (β-ARs), XRC structures a...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Taylor and Francis
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38626/ |