The role of kinetic context in apparent biased agonism at GPCRs
Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usually inferred from pharmacological data with the a...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
Nature Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38578/ |