Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding

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Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding

Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface solvation layer may exceed that in bulk solvent, resulting in overestimation of the intrinsic protein−l...

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Bibliographic Details
Main Authors:	Dickson, Callum J., Hornak, Victor, Velez-Vega, Camilo, McKay, Daniel J.J., Reilly, John, Sandham, David A., Shaw, Duncan, Fairhurst, Robin A., Charlton, Steven J., Sykes, David A., Pearlstein, Robert, Duca, Jose S.
Format:	Article
Published:	American Chemical Society 2016
Online Access:	https://eprints.nottingham.ac.uk/38577/

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