Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding
Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface solvation layer may exceed that in bulk solvent, resulting in overestimation of the intrinsic protein−l...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38577/ |