Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity

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Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity

Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in China as with seasonal human H1N1 viruses. The sa...

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Bibliographic Details
Main Authors:	Xu, Guanlong, Zhang, Xuxiao, Gao, Weihua, Wang, Chenxi, Wang, Jinliang, Sun, Honglei, Sun, Yipeng, Guo, Lu, Zhang, Rui, Chang, Kin-Chow, Liu, Jinhua, Pu, Juan
Format:	Article
Published:	American Society for Microbiology 2016
Online Access:	https://eprints.nottingham.ac.uk/38544/

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