Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity
Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in China as with seasonal human H1N1 viruses. The sa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Microbiology
2016
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| Online Access: | https://eprints.nottingham.ac.uk/38544/ |