Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema

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Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema

Heterotrimeric guanine nucleotide–binding protein (G protein) signaling is a ubiquitous signaling system that links hundreds of G protein–coupled receptors (GPCRs) with four G protein signaling pathways. Two of these pathways, one mediated by Gq and G11 and the other by G12 and G13, are implicated i...

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Bibliographic Details
Main Authors:	John, Alison, E., Wilson, Michael, R., Habgood, Anthony, Porte, Joanne, Tatler, Amanda L., Stavrou, Anastasios, Miele, Gino, Jolly, Lisa, Knox, Alan J., Takata, Masao, Offermanns, Stefan, Jenkins, R. Gisli
Format:	Article
Published:	American Association for the Advancement of Science 2016
Online Access:	https://eprints.nottingham.ac.uk/38458/

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